Neoplasms of upper gastrointestinal tract, especially malignancy, are one of the leading causes of death worldwide.The advent of endoscopy has greatly facilitated the detection and diagnosis of gastrointestinal lesions.Although it has been shown that the combined use of cytology and biopsy renders the highest probability of detecting malignancy, th
Developments in gastrointestinal organoid cultures to recapitulate tissue environments
Culture platforms that closely mimic the spatial architecture, cellular diversity, and extracellular matrix composition of native tissues can serve as invaluable tools for a range of Positive Battery Terminal scientific discovery and biomedical applications.Organoids have emerged as a promising alternative to both traditional 2D cell culture and an
Apitoxin harvest affects population development but not the hygienic behavior of African-derived honey bees
The biological properties of apitoxin have prompted its production for use in human and animal health applications.However, the apitoxin harvest triggers a defense reaction in honeybee colonies, which includes the release of alarm pheromones (isopentyl acetate and 2-heptanone), which cause stress and could cause behavioral changes that influence th
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy.Targeting PDAC metabolism through amino acid restriction has emerged as a promising new strategy, with asparaginases, enzymes that deplete plasma glutamine and asparagine, reaching clinical tri